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Article

Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer

16 Mar 2016

Abstract excerpt

UNLABELLED: Disruption of the gene encoding Protein Tyrosine Kinase 6 (Ptk6) delayed differentiation and increased growth in the mouse intestine. However, Ptk6-null mice were also resistant to azoxymethane-induced colon tumorigenesis. To further explore functions of PTK6 in colon cancer, expression of epithelial and mesenchymal markers, as well as proliferation, migration, and xenograft tumor growth, was examined...

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PMID: 26983689
DOI: 10.1158/1541-7786.mcr-15-0450

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