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Article

Rack1 function in intestinal epithelia: regulating crypt cell proliferation and regeneration and promoting differentiation and apoptosis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2018

Cheng Zhuan-Fen, Pai Reetesh K, Cartwright Christine A

Abstract excerpt

Previously, we showed that receptor for activated C kinase 1 (Rack1) regulates growth of colon cells in vitro, partly by suppressing Src kinase activity at key cell cycle checkpoints, in apoptotic and cell survival pathways and at cell-cell adhesions. Here, we generated mouse models of Rack1 deficiency to assess Rack1's function in intestinal epithelia in vivo. Intestinal Rack1 deficiency resulted in...

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Identifiers

PMID: 28935684
DOI: 10.1152/ajpgi.00240.2017
PMCID: PMC5866376

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