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Article

Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology

21 Jul 2017

Abstract excerpt

Determining the exact pathogenesis of chronic gastrointestinal diseases remains difficult due to the complex in vivo environment. In this review we give an overview of the available epithelial cell culture systems developed to investigate pathophysiology of gastrointestinal diseases. Traditionally used two-dimensional (2D) immortalised (tumour) cell lines survive long-term, but are not genetically stable nor...

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PMID: 29238585
DOI: 10.1177/2050640617722903

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