Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002

Tatebayashi Yoshitaka, Miyasaka Tomohiro, Chui De-Hua, Akagi Takumi, Mishima Ken-ichi, Iwasaki Katsunori, Fujiwara Michihiro, Tanemura Kentaro, Murayama Miyuki, Ishiguro Koichi, Planel Emmanuel, Sato Shinji, Hashikawa Tsutomu, Takashima Akihiko

Abstract excerpt

The R406W tau mutation found in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) causes a hereditary tauopathy clinically resembling Alzheimer's disease. Expression of modest levels of the longest human tau isoform with this mutation under the control of the alpha-calciu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Association Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inclusion Bodies

Share to Memory Disorders

Share to Neurofibrillary Tangles

Share to Point Mutation

Share to Prosencephalon

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12368474
DOI: 10.1073/pnas.202205599
PMCID: PMC129794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12368474-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.PMID 12368474Read ↗

Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.Semantic proximity Read ↗

Accelerated filament formation from tau protein with specific FTDP‐17 missense mutationsSemantic proximity Read ↗

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.Semantic proximity Read ↗

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain.Semantic proximity Read ↗

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.Semantic proximity Read ↗

Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.Semantic proximity Read ↗

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.Semantic proximity Read ↗

Tau and neurodegeneration.Semantic proximity Read ↗

Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease.Semantic proximity Read ↗

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.Semantic proximity Read ↗

Tau protein and neurodegeneration.Semantic proximity Read ↗

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.