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Article

Haplotype structures and functional polymorphic variants of the drug target enzyme aromatase (CYP19A1) in South Indian population.

Medical oncology (Northwood, London, England) - 1 Jan 2013

Umamaheswaran Gurusamy, Dkhar Steven Aibor, Kalaivani Sekar, Anjana Raj, Revathy Mohan, Jaharamma Mohammad, Shree Kulumani Mahadevan Lakshmi, Kadambari Dharanipragada, Adithan Chandrasekaran

Abstract excerpt

CYP19A1 gene product aromatase (CYP19A1) is a 58-kDa protein and belongs to the member of the cytochrome P450 superfamily, which facilitates the bioconversion of estrogens from androgens. Single-nucleotide polymorphisms (SNPs) of CYP19A1 affect the activity of the enzyme and have been implicated in the association of estrogen-dependent disease, prognosis, therapeutic efficacy, and toxicity of third-generation...

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PMID: 23893151
DOI: 10.1007/s12032-013-0665-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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