Article
Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development.
Nature genetics - 1 Mar 2000
DeChiara T M, Kimble R B, Poueymirou W T, Rojas J, Masiakowski P, Valenzuela D M, Yancopoulos G D
Abstract excerpt
Receptor tyrosine kinases often have critical roles in particular cell lineages by initiating signalling cascades in those lineages. Examples include the neural-specific TRK receptors, the VEGF and angiopoietin endothelial-specific receptors, and the muscle-specific MUSK receptor. Many lineage-restricted receptor tyrosine kinases were initially identified as 'orphans' homologous to known receptors, and only...
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