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Article

Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.

Investigative ophthalmology & visual science - 1 Oct 2016

Alldredge Ashley, Fuhrmann Sabine

Abstract excerpt

PURPOSE: The scaffold protein Axin2 is an antagonist and universal target of the Wnt/β-catenin pathway. Disruption of Axin2 may lead to developmental eye defects; however, this has not been examined. The purpose of this study was to investigate the role of Axin2 during ocular and extraocular development in mouse. METHODS: Animals heterozygous and homozygous for a Axin2lacZ knock-in allele were analyzed at...

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Share to Axin Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

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Source

Open in PubMed Open full text

Identifiers

PMID: 27701636
DOI: 10.1167/iovs.15-18599
PMCID: PMC5054732

Genes

PAX6
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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