Article
RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila.
Development (Cambridge, England) - 1 Oct 1994
Campbell G, Göring H, Lin T, Spana E, Andersson S, Doe C Q, Tomlinson A
Abstract excerpt
We report the identification of RK2, a glial-specific homeodomain protein. RK2 is localized to the nucleus of virtually all embryonic and imaginal glial cells, with the exception of midline glia. Embryos mutant for the gene encoding RK2 are embryonic lethal but normal for early gliogenesis (birth, initial divisions and migration of glia) and axonogenesis (neuronal pathfinding and fasciculation). However, later in...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Drosophila
- Drosophila Proteins
- Genes, Insect
- Homeodomain Proteins
- In Situ Hybridization
- Molecular Sequence Data
- Mutagenesis
- Nerve Tissue Proteins