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Article

A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development.

Developmental cell - 1 Feb 2009

Liu Ya-Hsin, Jakobsen Janus S, Valentin Guillaume, Amarantos Ioannis, Gilmour Darren T, Furlong Eileen E M

Abstract excerpt

Nk-2 proteins are essential developmental regulators from flies to humans. In Drosophila, the family member tinman is the major regulator of cell fate within the dorsal mesoderm, including heart, visceral, and dorsal somatic muscle. To decipher Tinman's direct regulatory role, we performed a time course of ChIP-on-chip experiments, revealing a more prominent role in somatic muscle specification than previously...

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PMID: 19217429
DOI: 10.1016/j.devcel.2009.01.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development.PMID 19217429Read ↗

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Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network.Semantic proximity Read ↗

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.Semantic proximity Read ↗

The gene tinman is required for specification of the heart and visceral muscles in Drosophila.Semantic proximity Read ↗

The NK homeodomain transcription factor Tinman is a direct activator of seven-up in the Drosophila dorsal vessel.Semantic proximity Read ↗

Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster.Semantic proximity Read ↗

Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors.Semantic proximity Read ↗

Developmental paradigms in heart disease: insights from tinman.Semantic proximity Read ↗

Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5.Semantic proximity Read ↗

tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman.Semantic proximity Read ↗

Transcription factor neuromancer/TBX20 is required for cardiac function in <i>Drosophila</i> with implications for human heart diseaseSemantic proximity Read ↗

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