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Article

Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism.

Biological psychiatry - 1 Dec 2007

Adli Mazda, Hollinde Dorothea L, Stamm Thomas, Wiethoff Katja, Tsahuridu Martina, Kirchheiner Julia, Heinz Andreas, Bauer Michael

Abstract excerpt

BACKGROUND: Glycogen synthase kinase 3-beta (GSK3B) is a serine/threonine kinase which is directly inhibited by lithium. A -50T/C single nucleotide polymorphism (SNP) localized within the promoter region of the GSK3B gene has previously been shown to be associated with response to lithium prophylaxis in bipolar disorder. This study investigates the association of the GSK3B -50T/C SNP and response to lithium...

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Identifiers

PMID: 17628506
DOI: 10.1016/j.biopsych.2007.03.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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