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Article

Topology of amphipathic motifs mediating Golgi localization in ArfGAP1 and its splice isoforms.

The Journal of biological chemistry - 28 Mar 2008

Levi Sharon, Rawet Moran, Kliouchnikov Lena, Parnis Anna, Cassel Dan

Abstract excerpt

The interaction of the Arf1-directed GTPase-activating protein ArfGAP1 with the Golgi apparatus depends on motifs in its noncatalytic part that are unstructured in solution but are capable of folding into amphipathic helices in vitro upon interaction with poorly packed lipids. In previous studies a few hydrophobic residues that are critical for lipid binding and Golgi localization were identified, but the precise...

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Identifiers

PMID: 18195007
DOI: 10.1074/jbc.M709738200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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