Article
Mutation of a putative amphipathic alpha-helix in the third intracellular domain of the platelet-activating factor receptor disrupts receptor/G protein coupling and signaling.
Molecular pharmacology - 1 Mar 1998
Carlson S A, Chatterjee T K, Murphy K P, Fisher R A
Abstract excerpt
Platelet-activating factor (PAF) is a potent phospholipid mediator that interacts with G protein-coupled PAF receptors to elicit diverse physiological and pathophysiological actions. We recently demonstrated that the third intracellular domain of the rat PAF receptor (rPAFR) is a critical determi...
Topics
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Cricetinae
- GTP-Binding Proteins
- Molecular Sequence Data
- Mutation
- Platelet Membrane Glycoproteins
- Protein Structure, Secondary
- Rats
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled