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Article

The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation.

Molecular & cellular proteomics : MCP - 1 Jun 2026

Zhu Jiangli, Li Wenchao, Ji Mingyang, Chang Xue, Cao Yang, Gao Jun, Qi Shiqian, Kong Eryan

Abstract excerpt

ARF1 plays a crucial role in maintaining the structure and function of the Golgi apparatus, yet the precise on-site regulatory mechanism governing ARF1 activation remains incompletely understood. Here, we have uncovered a novel regulatory mechanism involving the palmitoylation of ARF1 at Cys159. Our findings in HEK293T cells demonstrate that ZDHHC8 is responsible for promoting ARF1 palmitoylation, while PPT2 is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42140426
DOI: 10.1016/j.mcpro.2026.101586
PMCID: PMC13273671

Genes

ARF1
PPT2
ZDHHC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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