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Article

Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission.

PloS one - 1 Jan 2014

Henry Stanley C, Schmidt Elyse A, Fessler Michael B, Taylor Gregory A

Abstract excerpt

The Immunity-Related GTPases (IRG) are a family of large GTPases that mediate innate immune responses. Irgm1 is particularly critical for immunity to bacteria and protozoa, and for inflammatory homeostasis in the intestine. Although precise functions for Irgm1 have not been identified, prior studies have suggested roles in autophagy/mitophagy, phagosome remodeling, cell motility, and regulating the activity of...

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PMID: 24751652
DOI: 10.1371/journal.pone.0095021
PMCID: PMC3994021

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