Article
Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis.
British journal of pharmacology - 1 Feb 2008
Kiriazis H, Wang K, Xu Q, Gao X-M, Ming Z, Su Y, Moore X-L, Lambert G, Gibbs M E, Dart A M, Du X-J
Abstract excerpt
BACKGROUND AND PURPOSE: The role of beta-adrenoceptors in heart disease remains controversial. Although beta-blockers ameliorate the progression of heart disease, the mechanism remains undefined. We investigated the effect of beta-adrenoceptors on cardiac hypertrophic growth using beta(1)- and beta(2)-adrenoreceptor knockout and wild-type (WT) mice. EXPERIMENTAL APPROACH: Mice were subjected to aortic banding or...
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