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Article

Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2018

You Jieyun, Wu Jian, Zhang Qi, Ye Yong, Wang Shijun, Huang Jiayuan, Liu Haibo, Wang Xiaoyan, Zhang Weijing, Bu Liping, Li Jiming, Lin Li, Ge Junbo, Zou Yunzeng

Abstract excerpt

Mechanical overload can be classified into pressure overload and volume overload, causing concentric and eccentric cardiac hypertrophy, respectively. Here, we aimed to differentiate the load-mediated signaling pathways involved in pressure versus volume overload cardiac hypertrophy. Pressure or volume overload was imposed on C57BL/6J mice by transverse aortic constriction (TAC) or aortic regurgitation (AR),...

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Share to Aorta
Share to Arterial Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomechanical Phenomena

Share to Hypertrophy, Left Ventricular

Share to Myocardial Contraction

Share to Stress, Mechanical

Share to Ventricular Function, Left

Share to Ventricular Remodeling

Source

Identifiers

PMID: 29196344
DOI: 10.1152/ajpheart.00212.2017

Genes

AR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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