Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy.

British journal of pharmacology - 1 Dec 2013

Yasuno Shinji, Kuwahara Koichiro, Kinoshita Hideyuki, Yamada Chinatsu, Nakagawa Yasuaki, Usami Satoru, Kuwabara Yoshihiro, Ueshima Kenji, Harada Masaki, Nishikimi Toshio, Nakao Kazuwa

Abstract excerpt

BACKGROUND AND PURPOSE: Angiotensin II has been implicated in the development of various cardiovascular ailments, including cardiac hypertrophy and heart failure. The fact that inhibiting its signalling reduced the incidences of both sudden cardiac death and heart failure in several large-scale clinical trials suggests that angiotensin II is involved in increased cardiac arrhythmogenicity during the development...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin II Type 1 Receptor Blockers
Share to Anti-Arrhythmia Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels, L-Type

Share to Cardiomegaly

Share to Connexin 43

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to Receptor, Angiotensin, Type 1

Share to Tachycardia, Ventricular

Source

Open in PubMed Open full text

Identifiers

PMID: 23937445
DOI: 10.1111/bph.12328
PMCID: PMC3838685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy.PMID 23937445Read ↗

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.Semantic proximity Read ↗

Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure.Semantic proximity Read ↗

Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.Semantic proximity Read ↗

Differential Role of Aldosterone and Transforming Growth Factor beta-1 in Cardiac RemodellingSemantic proximity Read ↗

Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.Semantic proximity Read ↗

Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice.Semantic proximity Read ↗

Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.Semantic proximity Read ↗

Roles of alpha1A- and alpha1B-adrenoceptors in heart: insights from studies of genetically modified mice.Semantic proximity Read ↗

Genetic and phenotypic targeting of beta-adrenergic signaling in heart failure.Semantic proximity Read ↗

Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse modelsSemantic proximity Read ↗

Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.Semantic proximity Read ↗

TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.