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Article

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2006

Zhang Ying-Min, Bo Jacqueline, Taffet George E, Chang Jiang, Shi Jianjian, Reddy Anilkumar K, Michael Lloyd H, Schneider Michael D, Entman Mark L, Schwartz Robert J, Wei Lei

Abstract excerpt

Ventricular myocyte hypertrophy is an important compensatory growth response to pressure overload. However, pathophysiological cardiac hypertrophy is accompanied by reactive fibrosis and remodeling. The Rho kinase family, consisting of ROCK1 and ROCK2, has been implicated in cardiac hypertrophy a...

Read the complete abstract on PubMed

Topics

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Share to Cardiomegaly
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Intracellular Signaling Peptides and Proteins

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Share to rho-Associated Kinases

Share to Ventricular Remodeling

Source

Identifiers

PMID: 16675849
DOI: 10.1096/fj.05-5129com

Genes

ROCK1
ROCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16675849-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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