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Article

Disruption of PDGFRalpha-initiated PI3K activation and migration of somite derivatives leads to spina bifida.

Development (Cambridge, England) - 1 Feb 2008

Pickett Elizabeth A, Olsen Gregory S, Tallquist Michelle D

Abstract excerpt

Spina bifida, or failure of the vertebrae to close at the midline, is a common congenital malformation in humans that is often synonymous with neural tube defects (NTDs). However, it is likely that other etiologies exist. Genetic disruption of platelet-derived growth factor receptor (PDGFR) alpha results in spina bifida, but the underlying mechanism has not been identified. To elucidate the cause of this birth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

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Identifiers

PMID: 18192285
DOI: 10.1242/dev.013763
PMCID: PMC2928559

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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