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Article

Kir2.1 is important for efficient BMP signaling in mammalian face development.

Developmental biology - 1 Dec 2018

Belus Matthew T, Rogers Madison A, Elzubeir Alaaeddin, Josey Megan, Rose Steven, Andreeva Viktoria, Yelick Pamela C, Bates Emily A

Abstract excerpt

Mutations that disrupt the inwardly rectifying potassium channel Kir2.1 lead to Andersen-Tawil syndrome that includes periodic paralysis, cardiac arrhythmia, cognitive deficits, craniofacial dysmorphologies and limb defects. The molecular mechanism that underlies the developmental consequences of inhibition of these channels has remained a mystery. We show that while loss of Kir2.1 function does not affect...

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Identifiers

PMID: 29571612
DOI: 10.1016/j.ydbio.2018.02.012
PMCID: PMC6148416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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