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Article

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.

Neuron - 10 Jan 2008

Romero Eliana, Cha Guang-Ho, Verstreken Patrik, Ly Cindy V, Hughes Robert E, Bellen Hugo J, Botas Juan

Abstract excerpt

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by expansion of a translated CAG repeat in the N terminus of the huntingtin (htt) protein. Here we describe the generation and characterization of a full-length HD Drosophila model to reveal a previously unknown disease mechanism that occurs early in the course of pathogenesis, before expanded htt is imported into the nucleus in...

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Identifiers

PMID: 18184562
DOI: 10.1016/j.neuron.2007.11.025
PMCID: PMC2277511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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