Article

Huntingtin is a cell-autonomous regulator of neuropeptide trafficking and clock output

2026-07-26

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease is a severe neurodegenerative condition arising from an abnormal CAG repeat expansion in the HTT gene, which leads to the production of a mutant Huntingtin protein carrying an extended polyglutamine stretch. Although the field has largely centred on the toxic effects gained by this mutant protein, growing evidence points to the loss of normal wild-type Huntingtin function a...

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Literature Corpus work: dfcc69dc-f15b-5159-acd1-606ae02d6af6
DOI: 10.64898/2026.07.22.740122

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