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Article

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.

BMC genomics - 13 Mar 2012

Lejeune François-Xavier, Mesrob Lilia, Parmentier Frédéric, Bicep Cedric, Vazquez-Manrique Rafael P, Parker J Alex, Vert Jean-Philippe, Tourette Cendrine, Neri Christian

Abstract excerpt

BACKGROUND: A central goal in Huntington's disease (HD) research is to identify and prioritize candidate targets for neuroprotective intervention, which requires genome-scale information on the modifiers of early-stage neuron injury in HD. RESULTS: Here, we performed a large-scale RNA interference screen in C. elegans strains that express N-terminal huntingtin (htt) in touch receptor neurons. These neurons...

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Identifiers

PMID: 22413862
DOI: 10.1186/1471-2164-13-91
PMCID: PMC3331833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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