Article

Identification of novel therapeutic targets for polyglutamine toxicity disorders that target mitochondrial fragmentation

2021-10-20

Abstract excerpt

Huntington’s disease (HD) is one of at least nine polyglutamine toxicity disorders caused by a trinucleotide CAG repeat expansion, all of which lead to age-onset neurodegeneration. Mitochondrial dynamics and function are disrupted in HD and other polyglutamine toxicity disorders. While multiple studies have found beneficial effects from decreasing mitochondrial fragmentation in HD models by disrupting the mitochon...

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Literature Corpus work: 4345c1c8-1a52-5f2c-beeb-83a30cba8050
DOI: 10.1101/2021.10.19.465059

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