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Article

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Dec 2007

Lee Sung Hak, Jeong Eun Goo, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

NOTCH proteins (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) play crucial roles in embryonic development. Also, mounting evidence indicates that NOTCH contributes to the pathogenesis of hematopoietic and solid malignancies. Recent studies reported a high incidence of gain-of-function mutations of the NOTCH...

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Source

Identifiers

PMID: 18184405
DOI: 10.1111/j.1600-0463.2007.00751.x

Genes

NOTCH1
NOTCH2
NOTCH3
NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18184405-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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