Article
Mutations increased overexpression of Notch1 in T-cell acute lymphoblastic leukemia
1 Jan 2012
Abstract excerpt
BACKGROUND: The Notch signaling pathway is crucial in T-cell development, Notch1 mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). To investigate the feature of Notch1 mutation and its corresponding expression level in Chinese patients with T-ALL, detection of mutation and the expression level of Notch1 gene was preformed using RT-PCR, sequencing and real-time PCR respectively....
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