Kick it up a Notch: NOTCH1 activation in T-ALL.

Abstract excerpt

While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. A recent paper by Weng et al. (2004) demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the...

Topics

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• Receptors, Cell Surface
• Signal Transduction
• Transcription Factors
• Gene Expression Regulation, Neoplastic
• NOTCH1 gene
• Leukemia-Lymphoma, Adult T-Cell