Article
Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia.
Genes, chromosomes & cancer - 1 Apr 2008
Horsley Sharon W, Colman Susan, McKinley Mark, Bateman Caroline M, Jenney Meriel, Chaplin Tracy, Young Bryan D, Greaves Mel, Kearney Lyndal
Abstract excerpt
In a small fraction ( approximately 2%) of cases of childhood acute lymphoblastic leukemia (ALL) clinical presentation of leukemia is preceded, some 2-9 months earlier, by a transient, remitting phase of nonclassical aplastic anemia, usually in connection with infection. The potential "preleukemic" nature of this prodromal phase has not been fully explored. We have retrospectively analyzed the blood and bone...
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