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Article

Genome-wide analysis of cytogenetic aberrations in ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia.

British journal of haematology - 1 May 2012

Borst Louise, Wesolowska Agata, Joshi Tejal, Borup Rehannah, Nielsen Finn C, Andersen Mette K, Jonsson Olafur G, Wehner Peder S, Wesenberg Finn, Frost Britt-Marie, Gupta Ramneek, Schmiegelow Kjeld

Abstract excerpt

The chromosomal translocation t(12;21) resulting in the ETV6/RUNX1 fusion gene is the most frequent structural cytogenetic abnormality among patients with childhood acute lymphoblastic leukaemia (ALL). We investigated 62 ETV6/RUNX1-positive childhood ALL patients by single nucleotide polymorphism array to explore acquired copy number alterations (CNAs) at diagnosis. The mean number of CNAs was 2·82 (range 0-14)....

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Share to Chromosome Aberrations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

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Share to Core Binding Factor Alpha 2 Subunit

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 22404039
DOI: 10.1111/j.1365-2141.2012.09083.x

Genes

ETV6
RUNX1

Provenance

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Genome-wide analysis of cytogenetic aberrations in ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia.PMID 22404039Read ↗

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