Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia.

Blood - 29 Apr 2010

Bateman Caroline M, Colman Susan M, Chaplin Tracy, Young Bryan D, Eden Tim O, Bhakta Manoo, Gratias Eric J, van Wering Elisabeth R, Cazzaniga Giovanni, Harrison Christine J, Hain Richard, Ancliff Philip, Ford Anthony M, Kearney Lyndal, Greaves Mel

Abstract excerpt

Chimeric fusion genes are highly prevalent in childhood acute lymphoblastic leukemia (ALL) and are mostly prenatal, early genetic events in the evolutionary trajectory of this cancer. ETV6-RUNX1-positive ALL also has multiple ( approximately 6 per case) copy number alterations (CNAs) as revealed by genome-wide single-nucleotide polymorphism arrays. Recurrent CNAs are probably "driver" events contributing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 2 Subunit
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Oligonucleotide Array Sequence Analysis

Share to Oncogene Proteins, Fusion

Share to Polymorphism, Single Nucleotide

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Twins, Monozygotic

Source

Identifiers

PMID: 20061556
DOI: 10.1182/blood-2009-10-251413

Genes

ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia.PMID 20061556Read ↗

The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias.Semantic proximity Read ↗

Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblastic leukemia.Semantic proximity Read ↗

Genome-wide analysis of cytogenetic aberrations in ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia.Semantic proximity Read ↗

Whole-exome sequencing of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profilesSemantic proximity Read ↗

ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.Semantic proximity Read ↗

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.Semantic proximity Read ↗

Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes.Semantic proximity Read ↗

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

ETV6-RUNX1 fusion gene and additional genetic changes in infant leukemia: a genome-wide analysis.Semantic proximity Read ↗

Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.