Article
Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.
The Lancet. Oncology - 1 Dec 2015
Moriyama Takaya, Metzger Monika L, Wu Gang, Nishii Rina, Qian Maoxiang, Devidas Meenakshi, Yang Wenjian, Cheng Cheng, Cao Xueyuan, Quinn Emily, Raimondi Susana, Gastier-Foster Julie M, Raetz Elizabeth, Larsen Eric, Martin Paul L, Bowman W Paul, Winick Naomi, Komada Yoshihiro, Wang Shuoguo, Edmonson Michael, Xu Heng, Mardis Elaine, Fulton Robert, Pui Ching-Hon, Mullighan Charles, Evans William E, Zhang Jinghui, Hunger Stephen P, Relling Mary V, Nichols Kim E, Loh Mignon L, Yang Jun J
Abstract excerpt
BACKGROUND: Hereditary predisposition is rarely suspected for childhood acute lymphoblastic leukaemia (ALL). Recent reports of germline ETV6 variations associated with substantial familial clustering of haematological malignancies indicated that this gene is a potentially important genetic determinant for ALL susceptibility. Our aims in this study were to comprehensively identify ALL predisposition variants in...
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