Article

Allopurinol improves cardiovascular phenotypes of a mouse model for Williams–Beuren syndrome reducing redox stress

2025-08-06

Abstract excerpt

<h4>SUMMARY</h4> Cardiovascular disease represents the primary cause of morbidity in Williams-Beuren syndrome (WBS), a neurodevelopmental disorder resulting from a hemizygous deletion of 26–28 genes on chromosome 7q11.23. The clinical phenotype includes systemic hypertension, cardiac dysfunction, and progressive vascular remodelling, features that are further exacerbated by increased oxidative stress. Given the e...

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Literature Corpus work: 0b400d23-b0fd-571d-925c-8dc774e37047
DOI: 10.1101/2025.08.06.668870

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