Article
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice.
Clinical science (London, England : 1979) - 31 Aug 2023
Vieira Pimentel Renata Lúcia, Braga Janaína Félix, Velloso Elizabeth Portugal Pimenta, Lautner Roberto Queiroga, de Oliveira Marilene Luzia, Todiras Mihail, Alenina Natalia, Bader Michael, de Sousa Felipe Gaia, Beier Suzane Lilian, Santos Ras
Abstract excerpt
BACKGROUND: An unbalance in the renin-angiotensin (Ang) system (RAS) between the Ang II/AT1 and Ang-(1-7)/Mas axis appears to be involved in preeclampsia (PE), in which a reduction in Ang-(1-7) was observed. Here, we tested whether the reduction in the activity of the Ang-(1-7)/Mas axis could be a contributing factor for the development of PE, using Mas-deficient (Mas-/-) mice. METHODS AND RESULTS: Cardiovascular...
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