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Article

Influence of specific CD4+ T cells and antibodies on evolution of hypervariable region 1 during acute HCV infection.

Journal of hepatology - 1 Feb 2008

Scottà Cristiano, Garbuglia Anna Rosa, Ruggeri Lionello, Spada Enea, Laurenti Luca, Perrone Maria Paola, Girelli Gabriella, Mele Alfonso, Capobianchi Maria Rosaria, Folgori Antonella, Nicosia Alfredo, Del Porto Paola, Piccolella Enza

Abstract excerpt

BACKGROUND/AIMS: Several studies suggest that the evolutionary rate of HVR1 sequence in acute HCV hepatitis derives from the action of a continuous immune-driven positive selection. However, these studies have not been performed examining the relationship between HVR1 evolution and the development of specific immunity to autologous HVR1 sequences. METHODS: We performed a longitudinal analysis of HVR1 sequences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18180071
DOI: 10.1016/j.jhep.2007.09.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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