Article
Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection.
Journal of virology - 1 Aug 1994
Kato N, Ootsuyama Y, Sekiya H, Ohkoshi S, Nakazawa T, Hijikata M, Shimotohno K
Abstract excerpt
The hypervariable region 1 (HVR1) of the putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV) contains a sequence-specific immunological B-cell epitope that induces the production of antibodies restricted to the specific viral isolate, and anti-HVR1 antibodies are involved in t...
Topics
- Adult
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Chronic Disease
- DNA, Viral
- Epitopes
- Female
- Gene Frequency
- Genome, Viral
- Hepacivirus
- Hepatitis Antibodies
- Hepatitis C
- Hepatitis C Antibodies
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction