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Article

Dynamic coinfection with multiple viral subtypes in acute hepatitis C.

The Journal of infectious diseases - 15 Dec 2010

Smith Jennifer A, Aberle Judith H, Fleming Vicki M, Ferenci Peter, Thomson Emma C, Karayiannis Peter, McLean Angela R, Holzmann Heidemarie, Klenerman Paul

Abstract excerpt

INTRODUCTION: Acute hepatitis C virus (HCV) infection is rarely studied, but virus sequence evolution and host-virus dynamics during this early stage may influence the outcome of infection. Hypervariable region 1 (HVR1) is genetically diverse and under selective pressure from the host immune response. We analyzed HVR1 evolution by frequent sampling of an acutely infected HCV cohort. METHODS: Three or more...

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Identifiers

PMID: 21067369
DOI: 10.1086/657317
PMCID: PMC3107554

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