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Article

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice.

Gut - 1 Dec 2016

Prentoe Jannick, Verhoye Lieven, Velázquez Moctezuma Rodrigo, Buysschaert Caroline, Farhoudi Ali, Wang Richard, Alter Harvey, Meuleman Philip, Bukh Jens

Abstract excerpt

OBJECTIVE: HCV is a major cause of chronic liver disease worldwide, but the role of neutralising antibodies (nAbs) in its natural history remains poorly defined. We analysed the in vivo role of hypervariable region 1 (HVR1) for HCV virion properties, including nAb susceptibility. DESIGN: Analysis of HCV from human liver chimeric mice infected with cell-culture-derived prototype genotype 2a recombinant J6/JFH1 or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26589670
DOI: 10.1136/gutjnl-2015-310300
PMCID: PMC5136728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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