Article
Prevalence of HCV HVR1 insertions and their role in antibody evasion.
Hepatology (Baltimore, Md.) - 1 Jul 2025
Olesen Christina Holmboe, Collignon Laura, Velázquez-Moctezuma Rodrigo, Fanalista Margherita, Fahnøe Ulrik, Mollerup Sarah, Schneider Uffe V, Holmbeck Kenn, Bukh Jens, Prentoe Jannick
Abstract excerpt
BACKGROUND AND AIMS: Chronic HCV infection afflicts around 50 million people globally, causing ~250,000 deaths yearly. An effective vaccine needs to overcome high viral diversity and HCV's ability to evade neutralizing antibodies (NAbs). Rapid antigenic drift in the N-terminal motif of envelope protein E2, named HVR1, is critically involved in NAb evasion through an incompletely understood mechanism involving...
Read the complete abstract on PubMedTopics
- Humans
- Hepacivirus
- Immune Evasion
- Viral Envelope Proteins
- Hepatitis C, Chronic
- Antibodies, Neutralizing