Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Changes in hypervariable region 1 of the envelope 2 glycoprotein of hepatitis C virus in children and adults with humoral immune defects.

Journal of medical virology - 1 Mar 2003

Gaud Umesh, Langer Barbara, Petropoulou Theoni, Thomas Howard C, Karayiannis Peter

Abstract excerpt

The N-terminal end of the hepatitis C virus (HCV) envelope glycoprotein E2 contains a stretch of 27 amino acids that exhibit increased variability. This hypervariable region 1 (HVR-1), as it is normally referred to, is thought to contain epitopes that come under humoral immune attack. In the present study, 10 patients (5 children and 5 adults) with humoral immune defects and chronic HCV infection were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinemia
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Common Variable Immunodeficiency

Share to Complementarity Determining Regions

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Sequence Analysis, DNA

Share to Viral Envelope Proteins

Source

Identifiers

PMID: 12526045
DOI: 10.1002/jmv.10296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Changes in hypervariable region 1 of the envelope 2 glycoprotein of hepatitis C virus in children and adults with humoral immune defects.PMID 12526045Read ↗

Dynamics of hypervariable region 1 variation in hepatitis C virus infection and correlation with clinical and virological features of liver disease.Semantic proximity Read ↗

Comparison of the rate of sequence variation in the hypervariable region of E2/NS1 region of hepatitis C virus in normal and hypogammaglobulinemic patients.Semantic proximity Read ↗

Characterization of hypervariable region in hepatitis C virus envelope protein during acute and chronic infection.Semantic proximity Read ↗

Acceleration of Hepatitis C Virus Envelope Evolution in Humans Is Consistent with Progressive Humoral Immune Selection during the Transition from Acute to Chronic InfectionSemantic proximity Read ↗

Evolutionary trends of the first hypervariable region of the hepatitis C virus E2 protein in individuals with differing liver disease severity.Semantic proximity Read ↗

Using evolutionary tools to refine the new hypervariable region 3 within the envelope 2 protein of hepatitis C virus.Semantic proximity Read ↗

[Viral escape from humoral immune system by mutations in hypervariable region of HCV envelope protein and mechanism of persistent viral infection].Semantic proximity Read ↗

Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection.Semantic proximity Read ↗

The hypervariable region of the HCV genome changes sequentially during the progression of acute HCV infection to chronic hepatitis.Semantic proximity Read ↗

Ontogeny of hepatitis C virus (HCV) hypervariable region 1 (HVR1) heterogeneity and HVR1 antibody responses over a 3 year period in a patient infected with HCV type 2b.Semantic proximity Read ↗

A correlation between the heterogeneity of hypervariable region 1 of E2 glycoprotein of Hepatitis C virus (HCV) and HCV antibody profile: a case study.Semantic proximity Read ↗

Prevalence of HCV HVR1 insertions and their role in antibody evasion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.