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A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

5 Mar 2008

Abstract excerpt

Most antibodies induced by HIV-1 are ineffective at preventing initiation or spread of infection because they are either nonneutralizing or narrowly isolate-specific. Rare, "broadly neutralizing" antibodies have been detected that recognize relatively conserved regions on the envelope glycoprotein. Using stringently characterized, homogeneous preparations of trimeric HIV-1 envelope protein in relevant...

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PMID: 18322015
DOI: 10.1073/pnas.0800255105

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