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Article

Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors

27 Sept 2016

Abstract excerpt

BACKGROUND: HIV-1 typically develops resistance to any single antiretroviral agent. Combined anti-retroviral therapy to reduce drug-resistance development is necessary to control HIV-1 infection. Here, to assess the utility of a combination of antibody and fusion inhibitor treatments, we investigated the potency of monoclonal antibodies at neutralizing HIV-1 variants that are resistant to fusion inhibitors....

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PMID: 27670680
DOI: 10.1186/s12977-016-0304-7

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