Article

Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning

2023-03-24

Abstract excerpt

Understanding the specificities of human serum antibodies that broadly neutralize HIV can inform prevention and treatment strategies. Here we describe a deep mutational scanning system that can measure the effects of combinations of mutations to HIV envelope (Env) on neutralization by antibodies and polyclonal serum. We first show that this system can accurately map how all functionally tolerated mutations to Env...

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Literature Corpus work: 0cd44fe0-0bab-53ad-bf1b-743663d09f54
DOI: 10.1101/2023.03.23.533993

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