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Article

Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning.

Cell host & microbe - 12 Jul 2023

Radford Caelan E, Schommers Philipp, Gieselmann Lutz, Crawford Katharine H D, Dadonaite Bernadeta, Yu Timothy C, Dingens Adam S, Overbaugh Julie, Klein Florian, Bloom Jesse D

Abstract excerpt

Understanding the specificities of human serum antibodies that broadly neutralize HIV can inform prevention and treatment strategies. Here, we describe a deep mutational scanning system that can measure the effects of combinations of mutations to HIV envelope (Env) on neutralization by antibodies and polyclonal serum. We first show that this system can accurately map how all functionally tolerated mutations to...

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Share to Antibodies, Monoclonal
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to Epitopes

Share to HIV Antibodies

Share to HIV Envelope Protein gp120

Share to HIV Infections

Source

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Identifiers

PMID: 37327779
DOI: 10.1016/j.chom.2023.05.025
PMCID: PMC10351223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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