Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities.

Abstract excerpt

Simian immunodeficiency virus (SIV) of macaques isolate SIVmac239 is highly resistant to neutralization by polyclonal antisera or monoclonal antibodies, a property that it shares with most primary isolates of human immunodeficiency virus type 1 (HIV-1). This resistance is important for the ability of the virus to persist at high levels in vivo. To explore the physical features of the viral envelope complex that...

Topics

• Animals
• Antibodies, Monoclonal
• Antibodies, Viral
• Antibody Specificity
• HIV Envelope Protein gp120
• HIV Envelope Protein gp41
• Immunoglobulin Fab Fragments
• Macaca mulatta
• Mice
• Mutation