Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.

doi:10.1016/j.ebiom.2016.08.045

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Article

Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.

EBioMedicine - 1 Oct 2016

Bradley Todd, Trama Ashley, Tumba Nancy, Gray Elin, Lu Xiaozhi, Madani Navid, Jahanbakhsh Fatemeh, Eaton Amanda, Xia Shi-Mao, Parks Robert, Lloyd Krissey E, Sutherland Laura L, Scearce Richard M, Bowman Cindy M, Barnett Susan, Abdool-Karim Salim S, Boyd Scott D, Melillo Bruno, Smith Amos B, Sodroski Joseph, Kepler Thomas B, Alam S Munir, Gao Feng, Bonsignori Mattia, Liao Hua-Xin, Moody M Anthony, Montefiori David, Santra Sampa, Morris Lynn, Haynes Barton F

Abstract excerpt

Most HIV-1 vaccines elicit neutralizing antibodies that are active against highly sensitive (tier-1) viruses or rare cases of vaccine-matched neutralization-resistant (tier-2) viruses, but no vaccine has induced antibodies that can broadly neutralize heterologous tier-2 viruses. In this study, we isolated antibodies from an HIV-1-infected individual that targeted the gp41 membrane-proximal external region (MPER)...

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Identifiers

PMID: 27612593
DOI: 10.1016/j.ebiom.2016.08.045
PMCID: PMC5078591

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