Article
Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2008
Sabatine Marc S, Ploughman Lynn, Simonsen Katy L, Iakoubova Olga A, Kirchgessner Todd G, Ranade Koustubh, Tsuchihashi Zenta, Zerba Kim E, Long Diane U, Tong Carmen H, Packard Christopher J, Pfeffer Marc A, Devlin James J, Shepherd James, Campos Hannia, Sacks Frank M, Braunwald Eugene
Abstract excerpt
OBJECTIVE: The purpose of this study was to investigate the association between the Ala227Pro polymorphism in the ADAMTS1 metalloproteinase gene and coronary heart disease and benefit from statin therapy in 2 independent cohorts. METHODS AND RESULTS: The frequency of the ADAMTS1 227Pro minor allele was 0.24 in 2421 male subjects from CARE, a randomized trial of pravastatin versus placebo. In the placebo arm,...
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