Article
Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis.
Circulation. Cardiovascular genetics - 1 Dec 2017
Salminen Aino, Vlachopoulou Efthymia, Havulinna Aki S, Tervahartiala Taina, Sattler Wolfgang, Lokki Marja-Liisa, Nieminen Markku S, Perola Markus, Salomaa Veikko, Sinisalo Juha, Meri Seppo, Sorsa Timo, Pussinen Pirkko J
Abstract excerpt
BACKGROUND: Matrix metalloproteinase 8 (MMP-8) is a proinflammatory enzyme expressed mainly by neutrophils. Elevated serum and plasma concentrations of MMP-8 are associated with the risk for and outcome of cardiovascular diseases (CVDs). The origin of circulating MMP-8 is not completely clear. METHODS AND RESULTS: We performed a genome-wide association study of serum MMP-8 levels in 2 populations comprising...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.