Article
Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions.
Circulation - 13 Jun 2017
Saleheen Danish, Zhao Wei, Young Robin, Nelson Christopher P, Ho WeangKee, Ferguson Jane F, Rasheed Asif, Ou Kristy, Nurnberg Sylvia T, Bauer Robert C, Goel Anuj, Do Ron, Stewart Alexandre F R, Hartiala Jaana, Zhang Weihua, Thorleifsson Gudmar, Strawbridge Rona J, Sinisalo Juha, Kanoni Stavroula, Sedaghat Sanaz, Marouli Eirini, Kristiansson Kati, Hua Zhao Jing, Scott Robert, Gauguier Dominique, Shah Svati H, Smith Albert Vernon, van Zuydam Natalie, Cox Amanda J, Willenborg Christina, Kessler Thorsten, Zeng Lingyao, Province Michael A, Ganna Andrea, Lind Lars, Pedersen Nancy L, White Charles C, Joensuu Anni, Edi Kleber Marcus, Hall Alistair S, März Winfried, Salomaa Veikko, O'Donnell Christopher, Ingelsson Erik, Feitosa Mary F, Erdmann Jeanette, Bowden Donald W, Palmer Colin N A, Gudnason Vilmundur, Faire Ulf De, Zalloua Pierre, Wareham Nicholas, Thompson John R, Kuulasmaa Kari, Dedoussis George, Perola Markus, Dehghan Abbas, Chambers John C, Kooner Jaspal, Allayee Hooman, Deloukas Panos, McPherson Ruth, Stefansson Kari, Schunkert Heribert, Kathiresan Sekar, Farrall Martin, Marcel Frossard Philippe, Rader Daniel J, Samani Nilesh J, Reilly Muredach P
Abstract excerpt
BACKGROUND: Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk. METHODS: We...
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