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Article

Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2006

Iakoubova Olga A, Tong Carmen H, Chokkalingam Anand P, Rowland Charles M, Kirchgessner Todd G, Louie Judy Z, Ploughman Lynn M, Sabatine Marc S, Campos Hannia, Catanese Joseph J, Leong Diane U, Young Bradford A, Lew David, Tsuchihashi Zenta, Luke May M, Packard Christopher J, Zerba Kim E, Shaw Peter M, Shepherd James, Devlin James J, Sacks Frank M

Abstract excerpt

OBJECTIVE: Statins reduce inflammation and risk of myocardial infarction (MI). Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin. METHODS...

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Source

Identifiers

PMID: 17008591
DOI: 10.1161/01.ATV.0000247248.76409.8b

Genes

FCAR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17008591-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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