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Article

Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels.

Circulation. Cardiovascular genetics - 1 Aug 2009

Cheng Yu-Ching, Kao Wen-Hong L, Mitchell Braxton D, O'Connell Jeffrey R, Shen Haiqing, McArdle Patrick F, Gibson Quince, Ryan Kathleen A, Shuldiner Alan R, Pollin Toni I

Abstract excerpt

BACKGROUND: Matrix metalloproteinase (MMP)-1 may play a role in cardiovascular disease susceptibility by influencing plaque rupture via its ability to degrade extracellular collagens. METHODS AND RESULTS: We performed a genome-wide association analysis of circulating MMP-1 levels using 500 K sing...

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Source

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Identifiers

PMID: 20031604
DOI: 10.1161/CIRCGENETICS.108.834986
PMCID: PMC2801898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20031604-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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